- Sickle-cell disease (SCD), or sickle-cell anaemia (or anemia; SCA) or drepanocytosis, is an autosomal co-dominant genetic blood disorder characterized by red blood cells that assume an abnormal, rigid, sicklemutation in the haemoglobin gene. Life expectancy is shortened, with studies reporting an average life expectancy of 42 in males and 48 in females .
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